Evaluate the Relationship Between Class 1 Integrons and Drug Resistance Genes in Clinical Isolates of Pseudomonas aeruginosa

• DOI: 10.2174/1874285801610010188
• Publication Date: 2016-12-05T04:38:33Z
• Authors: Seyed Mohammad Ja...; Niloofar Shoaee N...; Azad Khaledi; Seyede Fatemeh Da...; Davoud Esmaeili
• Keywords: Amikacin; Polymyxin

The prevalence of resistant Pseudomonas aeruginosa isolates is increasing and it considered as one the major public health concerns in world. association between integrons drug resistance has been proven evidences suggest that are coding responsible for dissemination antibiotic among P. isolates.This study aimed to evaluate relationship class 1 genes clinical from burn patients.100 were collected patients hospitalized skin ward Shahid Motahari hospital susceptibility testing was performed by disk diffusion method (Kirby-Bauer). Then DNA extracted PCR technique detection genes. data analyzed using SPSS software.The most effective polymyxin B with sensitivity 100%, observed ciprofloxacin (93%) amikacin (67%), respectively. maximum lowest frequencies belonged aac (6 ') - 1, VEB-1 rate 93% 10%, statistical Chi-square test did not find any significant correlation (p˃ 0.05).Although no observed, but antibiotics tested high. So, surveillance, optimization strict consideration antimicrobial use control infection necessary.