Probability of Soluble Tissue Factor Release Lead to the Elevation of D-dimer as a Biomarker for Traumatic Brain Injury

• DOI: 10.2176/nmc.oa.2018-0254
• Publication Date: 2019-01-22T22:29:21Z
• Authors: Eiichi SUEHIRO; Yuichi FUJIYAMA; Miwa KIYOHIRA; Yukari MOTOKI; Junzo NOJIMA; Michiyasu SUZUKI
• Keywords: Lead (geology); D-dimer; Elevation (ballistics)

d-dimer is a potential biomarker for the detection of traumatic brain injury (TBI). However, mechanisms that trigger elevation in TBI remain unclear. The purpose this study was to evaluate reliability blood as and determine involved regulating its levels. Nine patients with moderate severe isolated (Glasgow Coma Scale [GCS] score 7–13) were admitted our hospital from May 2013 June 2014. Blood samples collected systemic arteries on arrival at 1, 3, 5, 7 days after injury. levels neuron specific enolase (NSE), d-dimer, soluble tissue factor (sTF) measured. NSE (33.4 ng/ml: normal <12.0 ng/ml) (56.1 μg/ml: <1.0 μg/ml) elevated admission declined day 1 At admission, there significant correlations (R = 0.727, P 0.026) sTF 0.803, 0.009) level accurately reflects degree damage indicated by Our data suggest release induced may activate coagulation cascade, leading d-dimer.