ETS-1 Expression Is Hypoxia-independent in Glioblastoma-derived Endothelial and Mesenchymal Stem-like Cells

• DOI: 10.21873/anticanres.12601
• Publication Date: 2018-06-06T18:30:41Z
• Authors: DOMINIK KOESSINGER; VALERIE ALBRECHT; FLORIAN FABER; IRENE JAEHNERT; CHRISTIAN SCHICHOR
• Keywords: Hypoxia

Tumor cells infiltrating the brain are a typical hallmark of glioblastoma. Invasiveness glioma has been associated with ETS proto-oncogene 1 (ETS-1). In non-glial tumors, ETS-1 expression linked to hypoxia. However, it is not known whether hypoxia regulates in glioblastoma.The spatial distribution primary glioblastoma was assessed using immunohistochemistry. glioblastoma-derived mesenchymal stem-like (gbMSLCs) determined immunocytochemistry. The effect on gbMSLCs, cell lines and endothelial polymerase chain reaction immunoblotting.Our immunohistochemical studies revealed stromal cells. Stromal correlated microvessel density. gbMSLCs were found express ETS-1. all examined lines, transcription independent hypoxia.In glioblastoma, ETS-1-expression dependent hypoxia, but correlates tumor vascularization.