Suboptimal Outcomes in Cutaneous Squamous Cell Cancer of the Head and Neck with Nodal Metastases

• DOI: 10.21873/anticanres.12923
• Publication Date: 2018-10-01T21:49:35Z
• Authors: VAMSI VARRA; NEIL M. WOODY; CHANDANA REDDY; NIKHIL P. JOSHI; JESSICA GEIGER; DAVID J. ADELSTEIN; BRIAN B. BURKEY; JOSEPH SCHARPF; BRANDON PRENDES; ERIC D. LAMARRE; ROBERT LORENZ; BRIAN GASTMAN; BINDU V. MANYAM; SHLOMO A. KOYFMAN
• Keywords: Squamous cell cancer

There are limited data regarding survival, failure patterns, and factors associated with disease recurrence in patients cutaneous squamous cell cancer of the head neck (cSCC-HN) nodal metastases.A retrospective analysis cSCC-HN metastatic to cervical and/or parotid lymph nodes treated surgery post-operative radiation therapy was performed.This study included 76 (57 immunocompetent 18 immunosuppressed) a median follow-up months. Overall disease-free survival (DFS), (DR) at 2 years 60%, 49%, 40%, respectively. Immunosuppressed had significantly lower 2-year DFS (28% vs. 55%; p=0.003) higher DR (61% 34%; p=0.04) compared patients. Analysis demonstrated extracapsular extension (ECE) as only factor (p<0.0001).Patients metastases from have suboptimal outcomes. ECE immunosuppression were DR.