Lymphocyte–to–Monocyte Ratio and Prognostic Nutritional Index Predict Poor Prognosis in Patients on Chemotherapy for Unresectable Pancreatic Cancer

• DOI: 10.21873/anticanres.13331
• Publication Date: 2019-04-05T21:55:50Z
• Authors: TETSUNOSUKE SHIMIZU; KOHEI TANIGUCHI; MITSUHIRO ASAKUMA; ATSUSHI TOMIOKA; YOSHIHIRO INOUE; KOJI KOMEDA; FUMITOSHI HIROKAWA; KAZUHISA UCHIYAMA
• Keywords: Male; Prognosis; Monocytes; 3. Good health; Pancreatic Neoplasms; 03 medical and health sciences; Nutrition Assessment; 0302 clinical medicine; Humans; Female; Lymphocytes; Aged

Recently, several systemic inflammation-based scores, such as neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte (PLR), lymphocyte-to-monocyte (LMR), modified Glasgow prognostic score (GPS), and nutritional index (PNI), have been proposed factors for cancers. In this study, we aimed to determine the influence of scores nutrition status on outcome in patients receiving chemotherapy unresectable pancreatic cancer.A total 93 consecutive who underwent cancer at Osaka Medical College Hospital, Takatsuki, Japan, between January 2008 December 2014 were eligible study. The outcomes assessment included one- two-year overall survival (OS) rates, according changes LMR PNI prior to, following chemotherapy.LMR<3.4 (OR=5.02, 95%CI=1.559-19.85, p=0.005) PNI<43 (OR=3.53, 95%CI=1.057-14.21, p=0.03) independently predicted a poor using multivariate analysis. According chemotherapy, compared maintained LMR≥3.4, whose decreased from ≥3.4 <3.4 had significantly lower OS rates (p<0.001). Similarly, PNI≥43, deteriorated (56.2% versus 25.8% one year, 12.5% 0% two years; p=0.003).LMR<3.4 are identified independent predictors cancer. may help clinicians identify high risk prognosis.