Association Between PD-L1 and Histatin1, 3 Expression in Advanced Head and Neck Squamous Cell Carcinoma

• DOI: 10.21873/anticanres.15747
• Publication Date: 2022-05-10T10:45:19Z
• Authors: WASSAPOL WONGPANU...; SOMCHAI YODSANGA; RISA CHAISUPARAT; PANOMWAT AMORNPHI...
• Keywords: Tissue microarray

The prognosis of advanced stage head and neck squamous cell carcinoma (HNSCC) has remained unimproved for the past decades. Therefore, novel diagnostic markers treatment options are required. Recently, an inhibitor immune checkpoint program death ligand-1 (PD-L1), was approved by FDA, used in HNSCC patients. Histatins (HTNs), one common antimicrobial peptides saliva, have demonstrated wound healing antifungal capabilities other functions on oral epithelium. Dysregulation HTN1 HTN3 also been reported through genomic proteomic studies. This study aimed to investigate association between histatins (HTN1 HTN3) PD-L1 HNSCC.Data gene expression were collected from TCGA analyzed using a data-mining platform website (https://ualcan.path.uab.edu/). Tissue microarrays containing 98 samples patients non-neoplastic controls immunolabeled against PD-L1, HTN1, HTN3. immunohistochemistry results quantified ImageJ.The significantly higher tumors than normal tissues (p<0.001), but no significant difference found regarding Metastatic exhibited (p<0.018), compared non-metastatic group. Association Pearson correlation coefficient (r=0.603, p<0.001). No overall survival evident among our samples.PD-L1 associated with progression HNSCC. correlated that