Preoperative Myosteatosis and Prognostic Nutritional Index Predict Survival in Older Patients With Resected Biliary Tract Cancer

• DOI: 10.21873/cdp.10301
• Publication Date: 2024-05-09T08:00:31Z
• Authors: MASASHI UTSUMI; MASARU INAGAKI; KOJI KITADA; NAOYUKI TOKUNAGA; KOSUKE YUNOKI; YUYA SAKURAI; HIROKI OKABAYASHI; RYOSUKE HAMANO; HIDEAKI MIYASOU; YOUSUKE TSUNEMITSU; SHINYA OTSUKA
• Keywords: Univariate analysis; Bile duct cancer

Background/Aim: Sarcopenia accompanied by systemic inflammation is associated with poor prognosis in patients cancer. This study evaluated the prognostic significance of sarcopenia (myopenia and myosteatosis) inflammatory markers older (aged ≥80 years) resected biliary tract Patients Methods: who underwent resection for cancer between July 2010 January 2023 at NHO Fukuyama Medical Center were retrospectively reviewed. Preoperative computed tomography measured myopenia myosteatosis, using psoas muscle index modified intramuscular adipose tissue content. Associations clinicopathological characteristics, inflammation-based scores, overall survival analyzed Cox proportional hazards models. Results: Univariate analysis revealed low C-reactive protein-to-albumin ratio (<0.125), nutritional (<42), content, higher T-stage (T3-4), lymph node metastasis, postoperative complications worse ≥ 80 (n=48). Multivariate identified (<42) (p=0.007), content (p=0.015), (T3-4) (p<0.001), metastasis (p=0.001), (p=0.017) as independent predictors survival. Conclusion: myosteatosis are factors These may be useful risk stratification clinical decision-making. Early interventions, such support physical exercise, improve outcomes after