High-Sensitivity C-Reactive Protein and Cancer

• DOI: 10.2188/jea.je20100128
• Publication Date: 2011-03-01T17:00:41Z
• Authors: Seounghee Lee; Jae-Won Choe; Hong-Kyu Kim; Joohon Sung
• Keywords: Male; 0301 basic medicine; Prostatic Neoplasms; Adenocarcinoma; Middle Aged; 3. Good health; 03 medical and health sciences; C-Reactive Protein; Cross-Sectional Studies; Risk Factors; Stomach Neoplasms; Neoplasms; Colonic Neoplasms; Republic of Korea; Biomarkers, Tumor; Carcinoma, Squamous Cell; Humans; Original Article; Female; Thyroid Neoplasms; Aged

Background: High-sensitivity C-reactive protein (hs-CRP) is a commonly used inflammatory marker. The association between hs-CRP and cancer less consistent than that cardiovascular diseases. This study explored the cancer, using large database of Korean health examination records.Methods: A total 80 781 Koreans who visited promotion center general hospital were included. There 729 cases any primary site during 3-year period. Subjects with known or condition capable affecting excluded.Results: Serum was significantly higher in (2.9 mg/L) non-cases (1.4 mg/L; P < 0.0001). With lowest category (<1 as reference, crude odds ratios (ORs) for 1.36 (95% confidence interval [CI] = 1.16–1.62) second highest (1–3 2.49 CI 2.02–3.07) (>3 mg/L), adjusted ORs 1.16 0.95–1.42) 1.94 1.51–2.51) category. After excluding detected within 1 year after check-up, associations remained, although reduced number (n 88) attenuated significance associations.Conclusions: positively associated risk causality cannot be inferred this cross-sectional study. results support hypothesis chronic inflammation plays role cancer.