Repetitive Transcranial Magnetic Stimulation With and Without Internet-Delivered Cognitive-Behavioral Therapy for the Treatment of Resistant Depression: Protocol for Patient-Centered Randomized Controlled Pilot Trial

• DOI: 10.2196/18843
• Publication Date: 2020-08-11T18:34:29Z
• Authors: Rabab M Abou El-Magd; Gloria Obuobi-Donkor; Medard K Adu; Christopher Lacho...; Surekha Duddumpudi; Mobolaji A Lawal; Adegboyega O Sapara; Michael Achor; Maryam Kouzehgaran; Roshan Hegde; Corina Chew; Mike Mach; Shelley Daubert; Liana Urichuk; Mark Snaterse; Shireen Surood; Daniel Li; Andrew Greenshaw; Vincent Israel Op...
• Keywords: Depression; Treatment-Resistant Depression

Major depression is a severe, disabling, and potentially lethal clinical disorder. Only about half of patients respond to an initial course antidepressant pharmacotherapy. At least 15% all with major depressive disorder (MDD) remain refractory any treatment intervention. By the time that patient has experienced 3 definitive failures, likelihood achieving remission fourth option offered below 10%. Repetitive transcranial magnetic stimulation (rTMS) considered for MDD who are treatment. It not currently known if addition internet-delivered cognitive-behavioral therapy (iCBT) enhances patients' responses rTMS treatments.This study will evaluate comparative effectiveness without iCBT as innovative patient-centered intervention participants diagnosed treatment-resistant (TRD).This prospective, two-arm randomized controlled trial. In total, 100 resistant at psychiatric care clinic in Edmonton, Alberta, Canada, be one two conditions: (1) enrolment sessions alone (2) plus iCBT. Participants each group complete evaluation measures (eg, recovery, general symptomatology, functional outcomes) baseline, 1 month, months, 6 months. The primary outcome measure mean change scores on Hamilton Depression Rating Scale. Patient service utilization data clinician-rated also used gauge progress. analyzed descriptive statistics, repeated measures, correlational analyses.We expect results available 24 We hypothesize enrolled receive achieve superior outcomes comparison alone.The concomitant application psychotherapy been investigated previously. hope this project provide us concrete base practical efficacy using novel combination these modalities (rTMS iCBT).ClinicalTrials.gov NCT0423965; https://clinicaltrials.gov/ct2/show/NCT04239651.PRR1-10.2196/18843.