Using a Patient Portal to Increase Enrollment in a Newborn Screening Research Study: Observational Study

• DOI: 10.2196/30941
• Publication Date: 2022-02-10T14:30:25Z
• Authors: Lisa M Gehtland; Ryan S Paquin; Sara M Andrews; Adam M Lee; Angela Gwaltney; Martin Duparc; Emily R Pfaff; Donald B Bailey Jr
• Keywords: Patient portal; Receipt; Odds

Many research studies fail to enroll enough participants. Patient-facing electronic health record applications, known as patient portals, may be used send invitations eligible patients.The first aim was determine if receipt of a portal recruitment invitation associated with enrollment in large ongoing study newborns (Early Check). The second there were differences opening the and by race ethnicity, age, or rural/urban home address.We computable phenotype queried care system's clinical data warehouse identify women whose would likely eligible. Research sent through women's portals. We conducted logistic regressions test whether enrolled their after address.Research 4510 not yet portals between November 22, 2019, March 5, 2020. Among who received invitation, 3.6% (161/4510) within 27 days. odds enrolling among opened nearly 9 times did open (SE 3.24, OR 8.86, 95% CI 4.33-18.13; P<.001). On average, it took 3.92 days for newborn study, 64% (97/161) 1 day invitation. There disparities urbanicity but age. Black less than White 0.09, 0.29, 0.16-0.55; P<.001), urban zip codes more rural 0.97, 3.03, 1.62-5.67; P=.001). 0.05, 0.67, 0.57-0.78; P<.001) Hispanic 0.07, 0.73, 0.60-0.89; P=.002) compared women.Patient are an effective way recruit participants studies, substantial racial ethnic urban/rural status use study.ClinicalTrials.gov NCT03655223; https://clinicaltrials.gov/ct2/show/NCT03655223.