Harnessing Neuroplasticity to Promote Brain Health in Aging Adults: Protocol for the MOVE-Cog Intervention Study

• DOI: 10.2196/33589
• Publication Date: 2021-09-21T14:58:06Z
• Authors: Danylo F Cabral; Carrie A Hinchman; Christina Nunez; Jordyn Rice; David A Loewenstein; Lawrence P Cahalin; Tatjana Rundek; Alvaro Pascual-Leone; Joyce Gomes-Osman
• Keywords: Aerobic Exercise; Cognitive Training

Extensive evidence supports a link between aerobic exercise and cognitive improvements in aging adults. A major limitation with existing research is the high variability response to exercise. Our incomplete understanding of mechanisms that influence this low adherence are critical knowledge gaps barriers for systematic implementation promoting health aging.We aimed provide an in-person remotely delivered intervention study protocol main goal informing gap on mechanistic action brain by characterizing important neuroplasticity, cardiorespiratory fitness response, genetics proposed underlie exercise.This open-label, 2-month, interventional neurologically healthy sedentary This was fully remote options. Participants underwent total 30 sessions, including screening session, 3 pretest (baseline) assessments, 24 moderate-to-vigorous posttest assessments. We recruited participants aged 55 years above, sedentary, cognitively healthy. Primary outcomes were function, fitness. Secondary included genetic factors, endothelium functional mobility postural control, questionnaires, depression, sleep. also explored feasibility, adherence, technology adaptability, compliance both protocols.The recruitment phase data collection have concluded. Results expected be published end 2021 or early 2022.The generated these studies will introduce tangible parameters guide development personalized prescription models maximal benefit Successful completion specific aims enable researchers acquire appropriate expertise design conduct testing interventions person delivered, likely more effective at adults.ClinicalTrials.gov NCT03804528; http://clinicaltrials.gov/ct2/show/NCT03804528.RR1-10.2196/33589.