Joint Effects of Long-Term Exposure to Ambient Fine Particulate Matter and Ozone on Asthmatic Symptoms: Prospective Cohort Study

• DOI: 10.2196/47403
• Publication Date: 2023-08-03T14:15:25Z
• Authors: Jiahong Xu; Yan Shi; Gongbo Chen; Yanfei Guo; Weiling Tang; Cuiling Wu; Shuru Liang; Zhongguo Huang; Guanhao He; Xiaomei Dong; Ganxiang Cao; Pan Yang; Ziqiang Lin; Sui Zhu; Fan Wu; Tao Liu; Wenjun Ma
• Keywords: Effect modification

The associations of long-term exposure to air pollutants in the presence asthmatic symptoms remain inconclusive and joint effects as a mixture are unclear.We aimed investigate individual ambient fine particulate matter (PM2.5) daily 8-hour maximum ozone concentrations (MDA8 O3) Chinese adults.Data were derived from World Health Organization Study on Global Ageing Adult (WHO SAGE) cohort study among adults aged 50 years or older, which was implemented 1 municipality 7 provinces across China during 2007-2018. Annual average MDA8 O3 PM2.5 at residential addresses estimated by an iterative random forest model satellite-based spatiotemporal model, respectively. Participants who diagnosed with asthma doctor taking asthma-related therapies experiencing related conditions within past 12 months recorded having symptoms. Cox proportional hazards regression association quantile g-computation model. A series subgroup analyses applied examine potential modifications some characteristics. We also calculated population-attributable fraction (PAF) attributed O3.A total 8490 older than included, follow-up duration 6.9 years. During periods, 586 (6.9%) participants reported Individual effect showed that risk positively associated (hazard ratio [HR] 1.12, 95% CI 1.01-1.24, for per quantile) (HR 1.18, 1.05-1.31, quantile). Joint equal increment 18% 1.05-1.33) increase symptoms, contributed more (68%) effects. PAFs attributable 2.86% (95% 0.17%-5.50%) 4.83% 1.42%-7.25%), respectively, while PAF 4.32% 1.10%-7.46%). greater obesity, urban areas, lower family income, used unclean household cooking fuel.Long-term may individually jointly smaller sum These findings informed importance asthma.