An In-Person and Online Intervention for Parkinson Disease (UPGRADE-PD): Protocol for a Patient-Centered and Culturally Tailored 3-Arm Crossover Trial

• DOI: 10.2196/65490
• Publication Date: 2025-05-02T15:00:43Z
• Authors: Michail Elpidoforou; Irene Grimani; Marianna Papadopo...; Nikolaos Papagian...; Anastasia Bougea; Athina-Maria Simitsi; Evangelos Sfikas; Ioanna Alexandratou; Ioanna Alefanti; Roubina Antonelou; Christos Koros; Ioanna Mavroyianni; Chrysa Chrysovits...; Leonidas Stefanis; Daphne Bakalidou
• Keywords: Crossover study

Background Dance for Parkinson’s Disease (DfPD) is a dance program individuals with Parkinson disease (PD). There lack of knowledge about the effect this on frailty and sarcopenia experienced by patients PD. In addition, no randomized controlled trial to date has investigated either possible differential effects in-person versus online DfPD or clinical parameters in Greek Objective We aimed assess efficacy, safety, feasibility culturally tailored patient-centered offered both early- midstage Methods This 3-arm crossover (in-person vs control) UPGRADE-PD (Upbeating Application Disease). The experimental period will be 10 months, including three 2-month interventional periods two 60-minute classes per week each group DfPD) control (nonintervention group), washout between 40 Assessments performed face-to-face at baseline end study include quality life, fatigue, depressive symptoms, stress, anxiety, sarcopenia, frailty, balance, cognitive functions, movement nonmovement PD BMI. Safety, feasibility, patient satisfaction intervention assessed as well. Results protocol was approved Medical Ethics Committee Eginition University Hospital September 2022 Research West Attica October 2023 funded 2023. first participant enrolled April 2023, currently ongoing conclude 2024. Conclusions results are expected show several well people living Greece. Trial Registration ClinicalTrials.gov NCT06220084; https://clinicaltrials.gov/study/NCT06220084 International Registered Report Identifier (IRRID) DERR1-10.2196/65490