Increased risk of osteoporosis in patients with chronic rhinosinusitis: prospective and genetic risk score studies (Preprint)

• DOI: 10.2196/preprints.54237
• Publication Date: 2023-11-05T04:24:21Z
• Authors: Weizhong Ding; Yimin Dong; Minglong Wu; Kai Xu; Kehan Song; Feng Li

<sec> <title>BACKGROUND</title> Previous studies have shown an association between inflammatory diseases and bone metabolism. </sec> <title>OBJECTIVE</title> This study explores the relationship chronic rhinosinusitis (CRS) incident osteoporosis. <title>METHODS</title> We used multivariate Cox regression analysis to explore CRS risk of osteoporosis at individual level in a prospective cohort from UK Biobank. also calculated poly-genetic score (PRS) using genome sequencing data Biobank participants investigated PGS <title>RESULTS</title> The hazard ratios (HRs) for were 1.23 (95% confidence interval (CI), 1.06 1.45), 1.22 CI, 1.05 1.43), 1.20 1.03 1.40) with CRS, respectively, after adjusting characteristics, lifestyle factors, comorbidities. In addition, we PRS each participant. All divided into low-, middle- high-risk groups according tertiles PRS. Compared low-risk group, middle-risk group (HR 1.06; 95% 1.00 1.10) 1.08; 1.17) associated significantly increased <title>CONCLUSIONS</title> Patients are more likely develop than those without. genetic susceptibility all predisposed higher These findings may help personalized treatments patients CRS.