Occupational exposure to hairdressing products and thyroid disrupting effects : protocol for an exploratory field study in French hairdressers (Preprint)

• DOI: 10.2196/preprints.65833
• Publication Date: 2025-03-17T13:40:06Z
• Authors: Anca Radauceanu; Amandine Cambrai-Erb; Benedicte Adet; Marie-Isabelle Ni...; Flavien Denis; Romain Pons
• Keywords: Preprint; Exploratory research

<sec> <title>BACKGROUND</title> Cosmetic legislation is ensuring the safety of cosmetics for consumers but not professional use. All around world, hairdressing sector constitutes a major occupational group including about 90% women continuously exposed to numerous chemical composing products, among them endocrine disrupting compounds such as resorcinol, parabens, phtalates, UV filters. The thyroid-disrupting chemicals are substances concern incidence thyroid dysfunction has increased recently worldwide and long-term consequences at neurodevelopmental level in offspring after in-utero expoure were highlighted. Few biomonitoring studies explored exposure disruptors hairdressers up date we found no data impact on hormones system. </sec> <title>OBJECTIVE</title> present study aimed assess resorcinol French analyze relationship with biological parameters, taking into account other (parabens, filters). <title>METHODS</title> A cross-sectional carried out 300 female aged 18-45 years compared 150 controls, who recruited by six health services. followed during 5-day working week individual salon levels (urinary (resorcinol, benzophenone-3, ethylhexyl methoxycinnamate’s metabolits) different time points, daily job tasks use hair inventory products) blood parameters (T3, T4, TSH, thyroglobulin, thyroperoxidase throglobulin antibodies). Information sociodempographics residence, alimentary tobacco consumption, personal care household career medical history was collected questionnaire. <title>RESULTS</title> inclusion population planned between 2023 2025. Until now, total XX subjects (XX belonging salons, unexposed) included Since rates salons (around 10%) 50%), below those estimated, period will be extended till 2026. Further, new partnership more services under study. <title>CONCLUSIONS</title> This provide evidence disruptors. results represent first France hairdressers, susceptible childbearing age. We proposed timely research based professionals designed following multidisciplinary approach biometrology epidemiology. collection both allow in-depth assessment workplace. Together these may strengthen tools risk diagnosis prevention salons.