The National Patient-Centered Clinical Research Network (PCORnet) Bariatric Study Cohort: Rationale, Methods, and Baseline Characteristics

• DOI: 10.2196/resprot.8323
• Publication Date: 2017-12-05T10:45:06Z
• Authors: Sengwee Toh; Laura J Rasmussen...; Emily E Harmata; Roy Pardee; Rosalinde Saizan; Elisha Malanga; Jessica L Sturtevant; Casie E Horgan; Jane Anau; Cheri D Janning; Robert D Wellman; R Yates Coley; Andrea J Cook; Anita P Courcoulas; Karen J Coleman; Neely A Williams; Kathleen M McTigue; David Arterburn; James McClay
• Keywords: Patient-centered outcomes; Baseline (sea); Comparative effectiveness research

Although bariatric procedures are commonly performed in clinical practice, long-term data on the comparative effectiveness and safety of different sustained weight loss, comorbidities, adverse effects limited, especially important patient subgroups (eg, individuals with diabetes, older patients, adolescents, minority patients).The objective this study was to create a population-based cohort patients who underwent 3 procedures-adjustable gastric band (AGB), Roux-en-Y bypass (RYGB), sleeve gastrectomy (SG)-to examine these both adults adolescents.We identified (20 79 years old) adolescents (12 19 primary (first observed) AGB, RYGB, or SG procedure between January 1, 2005 September 30, 2015 from 42 health systems participating Clinical Data Research Networks within National Patient-Centered Network (PCORnet). We extracted information demographics, encounters healthcare providers, diagnoses recorded during encounters, vital signs, laboratory test results patients' electronic records (EHRs). The outcomes interest included change, incidence major surgery-related events, diabetes remission relapse, collected for up 10 after initial procedure.A total 65,093 777 met eligibility criteria study. adult subcohort had mean age 45 predominantly female (79.30%, 51,619/65,093). Among non-missing race ethnicity information, 72.08% (41,248/57,227) were White, 21.13% (12,094/57,227) Black, 20.58% (13,094/63,637) Hispanic. average highest body mass index (BMI) year prior surgery 49 kg/m2. RYGB most common among (49.48%, 32,208/65,093), followed by (45.62%, 29,693/65,093) AGB (4.90%, 3192/65,093). adolescent 17 77.5% (602/777) female. known 67.3% (473/703) 22.6% (159/703) 18.0% (124/689) BMI preceding 53 majority received (60.4%, 469/777), (30.8%, 239/777) (8.9%, 69/777). A measurement (proxy follow-up) available 84.31% (44,978/53,351), 68.09% (20,783/30,521), 68.56% (7159/10,442) eligible at 3, 5 follow-up, respectively. corresponding proportion 82.0% (524/639), 49.9% (174/349), 38.8% (47/121) subcohort.Our is one largest cohorts United States. Patients geographically demographically diverse, which improves generalizability research findings allows examination treatment effect heterogeneity. Ongoing planned investigations will provide real-world evidence benefits risks used current practice.