Diffusion-Weighted and Dynamic Contrast-Enhanced MRI of Prostate Cancer: Correlation of Quantitative MR Parameters With Gleason Score and Tumor Angiogenesis

• DOI: 10.2214/ajr.11.6861
• Publication Date: 2011-11-22T21:08:59Z
• Authors: Aytekin Oto; Cheng Yang; Arda Kayhan; Maria Tretiakova; Tatjana Antic; Christine Schmid-...; Scott Eggener; Gregory S. Karczmar; Walter M. Stadler
• Keywords: Dynamic Contrast-Enhanced MRI; Dynamic contrast

The objective of our study was to investigate whether quantitative parameters derived from diffusion-weighted imaging (DWI) and dynamic contrast-enhanced MRI (DCE-MRI) correlate with Gleason score angiogenesis prostate cancer.Seventy-three patients who underwent preoperative radical prostatectomy were included in study. A radiologist pathologist located the dominant tumor on MR images based histopathologic correlation. For each tumor, apparent diffusion coefficient (ADC) value DCE-MRI (i.e., contrast agent transfer rate between blood tissue [K(trans)], extravascular extracellular fractional volume [v(e)], backflux constant [k(ep)], plasma a voxel-by-voxel basis [v(p)]) calculated recorded. mean vessel count, area fraction, vascular endothelial growth factor (VEGF) expression determined using CD31, CD34, VEGF antibody stains. Spearman correlation analysis conducted.The diameter 15.2 mm (range, 5-28 mm). Of 73 cancer tumors, five (6.8%) had 6, 46 (63%) 7, 22 (30.1%) greater than 7. ADC values showed moderate negative (r = -0.376, p 0.001) but did not parameters. Quantitative show significant or (p > 0.05). Mean count fraction estimated positively correlated k(ep) 0.440 0.453, respectively; 0.001 for both).There is microvessel density cancer. Although strength correlations insufficient immediate diagnostic utility, these results warrant further investigation potential multiparametric facilitate noninvasive assessment aggressiveness angiogenesis.