Comparison of Quantitatively Analyzed Dynamic Area-Detector CT Using Various Mathematic Methods With FDG PET/CT in Management of Solitary Pulmonary Nodules

• DOI: 10.2214/ajr.12.9197
• Publication Date: 2013-05-23T14:58:03Z
• Authors: Yoshiharu Ohno; Mizuho Nishio; Hisanobu Koyama; Yasuko Fujisawa; Takeshi Yoshikawa; Sumiaki Matsumoto; Kazuro Sugimura
• Keywords: Male; Contrast Media; Reproducibility of Results; Solitary Pulmonary Nodule; Multimodal Imaging; Sensitivity and Specificity; 3. Good health; 03 medical and health sciences; 0302 clinical medicine; ROC Curve; Fluorodeoxyglucose F18; Positron-Emission Tomography; Humans; Radiographic Image Interpretation, Computer-Assisted; Female; Prospective Studies; Radiopharmaceuticals; Tomography, X-Ray Computed; Aged

The objective of our study was to prospectively compare the capability dynamic area-detector CT analyzed with different mathematic methods and PET/CT in management pulmonary nodules.Fifty-two consecutive patients 96 nodules underwent CT, PET/CT, microbacterial or pathologic examinations. All were classified into following groups: malignant (n = 57), benign low biologic activity 15), high 24). On total, arterial, systemic arterial perfusions calculated using dual-input maximum slope method; perfusion single-input extraction fraction blood volume (BV) Patlak plot method. indexes statistically compared among three nodule groups. Then, receiver operating characteristic analyses used diagnostic capabilities standardized uptake value (SUVmax) each parameter having a significant difference between nodules. Finally, performances by means McNemar test.No adverse effects observed this study. except BV, both which method, showed differences groups (p < 0.05). Areas under curve total method significantly larger than that SUVmax accuracy (83.3%) greater other indexes: (72.9%, p 0.05), (69.8%, (66.7%, (60.4%, 0.05).Dynamic has better potential for diagnosis PET/CT.