Superselective intraarterial infusion of cisplatin for squamous cell carcinoma of the mouth: preliminary clinical experience.

• DOI: 10.2214/ajr.165.5.7572516
• Publication Date: 2013-03-01T09:20:49Z
• Authors: Y Korogi; T Hirai; R Nishimura; S Hamatake; Y Sakamoto; R Murakami; Y Baba; A Arakawa; M Takahashi; Y Uji
• Keywords: Aged, 80 and over; Male; Angiography; Angiography, Digital Subtraction; Middle Aged; Radiology, Interventional; Indigo Carmine; 3. Good health; 03 medical and health sciences; 0302 clinical medicine; Carcinoma, Squamous Cell; Humans; Infusions, Intra-Arterial; Female; Mouth Neoplasms; Cisplatin; Aged

The purpose of this study was to assess the initial clinical response superselective intraarterial infusion cisplatin for treating stage III and IV squamous cell carcinoma mouth.Thirteen patients received therapy. tumors were located in tongue (n = 7), gingiva 3), buccal mucosa 1), hard palate floor mouth 1). A coaxial technique used place microcatheters lingual, facial, inferior alveolar, buccinator, distal internal maxillary arteries, depending on tumor location. feeding vessels identified by staining with indigocarmine dye selected vessel. Relatively low-dose (30-40 mg/m2) injected at rate 50 mg/hr. Two or three injections performed, a 1-week interval between injections. After chemotherapy, eight underwent surgery, four had radiation therapy, one both.Thirty-four infusions done successfully without any complications. Arterial useful exact identification vessels, especially when extensive, margin arterial supply, near midline. overall 92% (complete [tumor completely resolved], 38%; partial reduction > 50%], 54%). Ten 13 no recurrence from 4 19 months (mean, 10 months) after treatment. died metastatic diseases 6 surgery One patient local 8 postoperative irradiation. No systemic toxicity such as renal failure, liver dysfunction, bone marrow suppression observed. Mild transient edema mucositis infused area relatively common. Trigeminal neuralgialike symptoms reduced opening occurred two cases case, respectively, probably due direct peripheral trigeminal nerve masticatory muscles, respectively.Superselective is feasible safe may have important applications advanced mouth.