Arohynapene A Produced by <i>Penicillium steckii</i> JB-NW-2-1 Isolated from <i>Avicennia marina</i> (Forssk.) Vierh and Its Cytotoxic Activities

• DOI: 10.22146/ijc.83982
• Publication Date: 2024-04-01T01:48:05Z
• Authors: Yeni Mulyani; Wahyu Syafriansyah; Asri Peni Wulandari; Azmi Azhari; Sari Purbaya; Aprilia Permata Sari; Galih Bayu Pratama; Fajar Fauzi Abdullah; Kindi Farabi; Unang Supratman; Yoshihito Shiono
• Keywords: Avicennia marina

Mangrove-associated endophytic fungi are producers of secondary metabolites in unique and diverse structures with interesting biological activities such as antiviral, antifungal, antibacterial, anti-inflammatory, cytotoxic agents. Endophytes play an important role the physiological host plants, influencing improvement resistance to stress, insects, nematodes, diseases. In this study, arohynapene A, a polyketide compound, was successfully isolated from mangrove-derived fungus Penicillium steckii JB-NW-2-1 obtained mangrove plant Avicennia marina (Forssk) Vierh. The structure determined by spectroscopic method including IR, MS, 1D-, 2D-NMR techniques. This compound evaluated for using resazurin assay against four cancer cells, HeLa cervical, MCF-7 breast cancer, B16-F10 melanoma, A549 lung adenocarcinoma. results showed no significant all cells tested (IC50 &gt; 500 µM).