Long-Term Treatment with Potassium Citrate and Renal Stones in Medullary Sponge Kidney

• DOI: 10.2215/cjn.00220110
• Publication Date: 2010-06-25T04:13:34Z
• Authors: Antonia Fabris; Antonio Lupo; Patrizia Bernich; Cataldo Abaterusso; Nicola Marchionna; Antonio Nouvenne; Giovanni Gambaro
• Keywords: Hyperuricosuria; Nephrocalcinosis; Renal tubular acidosis; Urinary calcium

Medullary sponge kidney (MSK) is a renal malformation typically associated with nephrocalcinosis and recurrent calcium stones. Incomplete distal tubular acidosis, hypocitraturia, hypercalciuria are common. For stone prevention, patients MSK generally receive the standard "stone clinic" recommendations often potassium citrate (KC). However, effect on recurrence of treatment in these has never been studied.The issue was retrospectively analyzed an outpatient basis 97 radiologic diagnosis MSK: 65 had at least one risk factor (SRF; hypercalciuria, hyperuricosuria, hyperoxaluria) received KC [29 +/- 8 (SD) mEq/d]; 10 SRF 22 without only general clinic suggestions. Follow-up 78 13, 72 15, 83 14 months, respectively. The 24-hour urinary excretion calcium, oxalate, uric acid, citrate, morning urine pH were investigated baseline end follow-up.Parallel to significant rise decreased (all P < 0.001), led dramatic reduction event rate (from 0.58 0.10 stones/yr per patient). existence group MSK, those SRF, very low no recognized.Treatment effective preventing stones typical patient MSK. It seems that two clinical phenotypes among showing features during study exist.