Serum Albumin as Predictor of Nutritional Status in Patients with ESRD

• DOI: 10.2215/cjn.10251011
• Publication Date: 2012-06-23T00:38:34Z
• Authors: Thiane Gama-Axelsson; Olof Heimbürger; Peter Stenvinkel; Peter Bárány; Bengt Lindholm; Abdul Rashid Qureshi
• Keywords: Serum Albumin; Albuminuria

Summary Background and objectives Serum albumin is a widely used biomarker of nutritional status in patients with CKD; however, its usefulness debated. This study investigated serum correlation several markers incident prevalent dialysis patients. Design, setting, participants, & measurements In cross-sectional study, (bromocresol purple), other biochemical (serum creatinine), clinical (subjective global assessment [SGA]), anthropometric (handgrip strength; skinfold thicknesses), densitometry (dual-energy x-ray absorptiometry) were assessed 458 (61% male; mean age, 54±13 years; GFR, 6.6±0.3 ml/min per 1.73 m 2 ; recruited 1994–2010) 383 (56% 62±14 1989–2004) Results patients, was correlated age ( β =−0.15; P <0.001), diabetes =−0.30; high-sensitivity C-reactive protein =−0.37; urinary excretion =−0.38; <0.001) but less so poor (SGA score > 1; =−0.19; <0.001). =−0.31; SGA 1 =−0.16; predicting by markers, adding to models that included sex, diabetes, cardiovascular disease did not significantly increase explanatory power. Conclusions correlates poorly status. Thus, value as reliable marker ESRD limited.