Short-term rhGH increases PIIINP, a biomarker of endothelial dysfunction

• DOI: 10.22161/ijaers.4.7.26
• Publication Date: 2017-08-01T11:26:28Z
• Authors: Graham M. R.; Gu Y.; Evans P. J.; Cooper S. M.; Davies B.; Baker J. S.
• Keywords: Endothelial Dysfunction

Objectives: In arterial hypertension, aminoterminal propeptide of type III procollagen (PIIINP) is elevated in aneurysm tissue and associated with a poor prognosis following acute myocardial infarction (MI).Recombinant human growth hormone (rhGH) administration attenuates endothelial dysfunction but increases PIIINP.This study was conducted to establish if short-term rhGH affects PIIINP, function selected cardiovascular disease (CVD) risk factors, healthy males.Design: Method: Male subjects (n=48) were randomly assigned into two groups: (1): control group (C) n=24, mean ± SD, age 32 11 years; height 1.8 0.06 metres; (2): 9 0.07 metres.Blood pressure (BP), heart rate (HR), pulse wave velocity (APWV), biochemical indices investigated.Results: PIIINP (0.28±0.1 vs. 0.42±0.2,U/ml); Insulin like factor-I (159±54 323±93, ng.mL -1 ); resting HR (72±14 78±11, b.p.m.) product (RPP) (90±18 97±14, bpm x mm.Hg 10 -2 ) all significantly increased (P<0.05).Total cholesterol (4.7±0.9 4.4±0.7,mmol.L high sensitivity C-reactive protein (1.77±2.1 1.29±1.6,mg.L serum homocysteine (13.2±4.0 11.7±3.1,μmol.L APWV (9.97±1.38 9.18±1.6,m.s decreased (P<0.05).Conclusion: Paradoxically, there an improvement CVD inflammatory markers APWV; RPP increased.Elevated may have confounding adverse effect on the endothelium, also provide clinical prognostic information monitoring left ventricular sub-acute phase MI aortic aneurysms.