3D optical coherence tomography for clinical diagnosis of nonmelanoma skin cancers

• DOI: 10.2217/iim.11.62
• Publication Date: 2011-12-03T18:37:09Z
• Authors: Aneesh Alex; Jessika Weingast; Bernd Hofer; Matthias Eibl; Michael Binder; Hubert Pehamberger; Wolfgang Drexler; Boris Považay
• Keywords: 0103 physical sciences; 01 natural sciences; 3. Good health

High-resolution frequency domain optical coherence tomography (OCT) stands out amongst a range of novel dermatologic imaging technologies, with its good detection sensitivity around -100 dB, high measurement speeds allowing real-time image acquisition and ability to acquire definition cross-sectional 3D tomograms regions greater than 1 cm2, providing tissue information comparable conventional histopathology without the need for any contrast agents. Typical axial transverse resolutions state-of-the-art OCT systems between 1–10 µm approximately 20 µm, respectively, depending on employed wavelength region. This review investigates significant progress accomplished in field respect other vivo diagnostic methods pre-excisional nonmelanoma skin cancers specifically emphasizes results achieved different clinical pilot studies. Further technological extensions OCT, various multimodal ap...