99mTc-tilmanocept for lymphoscintigraphy

• DOI: 10.2217/iim.13.11
• Publication Date: 2013-03-26T11:30:12Z
• Authors: Christopher A Puleo; Claudia Berman; Jaime L Montilla-...; Jonathan S Zager; Vernon K Sondak
• Keywords: 03 medical and health sciences; 0302 clinical medicine; 3. Good health

Vital blue dyes and radiolabeled colloids are widely used globally for intraoperative lymphatic mapping sentinel lymph node biopsy. Until very recently, however, no agents were specifically approved lymphoscintigraphy none have been tested in prospective clinical trials. 99mTc-tilmanocept was designed use biopsy, has evaluated Phase II III In nonrandomized, comparisons with vital dye, reproducibly localized regional nodes after injection at the site of primary breast carcinomas melanomas undergoing detecting nearly all visibly identifying more tumor-containing overall, without missing any nodes. A trial head neck squamous cell carcinomas, patients complete dissection removal detected 99mTc-tilmanocept, is currently underway...