The Significance of the Levels of IL-4, IL-31 and TLSP in Patients With Asthma and/or Rhinitis

• DOI: 10.2217/imt-2016-0131
• Publication Date: 2017-03-17T09:46:29Z
• Authors: Ruonan Chai; Beixing Liu; Feifei Qi
• Keywords: Adult; Male; Adolescent; Interleukins; Blood Proteins; Antigens, Plant; Immunoglobulin E; Interleukin-33; Asthma; 3. Good health; Disease Models, Animal; Mice; 03 medical and health sciences; 0302 clinical medicine; Artemisia; Animals; Cytokines; Humans; Female; Antigens, Dermatophagoides; Interleukin-4; Child; Cells, Cultured

To investigate the clinical significance of levels IL-4, IL-33 and thymic stromal lymphopoietin (TLSP) in patients with asthma and/or rhinitis, then do simple verification animals.Levels IL-4 IL-31, TLSP were detected by ELISA real-time PCR 64 (sIgE[+]: 32 cases, sIgE[-]: cases), rhinitis complicated allergic cases) healthy controls. Then we sensitized mice.Results showed that TSLP patients, those had significant differences compared control group (p < 0.05). It was found indicators mugwort dust mite significantly higher than other We got same tendency vivo experiments.IL-4, may be involved pathogenesis rhinitis; allergy could increase them significantly.