Essential role of CD4 + T cells for the activation of group 2 innate lymphoid cells during respiratory syncytial virus infection in mice

• DOI: 10.2217/imt-2019-0084
• Publication Date: 2019-09-03T11:07:46Z
• Authors: Xu Han; Song Bai; Yulin Cui; Wenwen Zhu; Na Zhao; Beixing Liu
• Keywords: Innate lymphoid cell

Aim: To investigate whether and how CD4+ T cells contribute to ILC2 activation during respiratory syncytial virus (RSV) infection. Methods: The methods of flow cytometry, quantitative PCR ELISA were used in the present study. Results: Depletion diminished numbers lung ILC2s as well their ability produce type 2 cytokines. cell-mediated is related IL-2. main cellular source IL-2 was cells. decreased levels lungs RSV-infected mice. can directly stimulate proliferation promote Treatment mice with neutralizing anti-IL-2 monoclonal antibodies activation. Conclusion: These results suggest that RSV-induced partly via producing