Prognostic Value of Intratumoral Lymphocyte-to-Monocyte Ratio and M0 Macrophage Enrichment in Tumor Immune Microenvironment of Melanoma

• DOI: 10.2217/mmt-2020-0019
• Publication Date: 2020-11-02T10:03:51Z
• Authors: Neil K Jairath; Mark W Farha; Ruple Jairath; Paul W Harms; Lam C Tsoi; Trilokraj Tejasvi
• Keywords: Monocyte; Tumor-infiltrating lymphocytes; Tumor-associated macrophage

Skin cutaneous melanoma is characterized by significant heterogeneity in its molecular, genomic and immunologic features. Whole transcriptome RNA sequencing data from The Cancer Genome Atlas of skin (n = 328) was utilized. CIBERSORT used to identify immune cell type composition, on which unsupervised hierarchical clustering performed. Analysis overall survival performed using Kaplan-Meier estimates multivariate Cox regression analyses. Membership the lymphocyte:monocytelow, monocytehi gh M0high cluster an independently poor prognostic factor for (HR: 3.03; 95% CI: 1.12-8.20; p 0.029) correlated with decreased predicted response checkpoint blockade. In conclusion, M0-macrophage-enriched, lymphocyte-to-monocyte-ratio-low phenotype primary tumor site characterizes aggressive that may differentially respond treatment.