Dura Mater Regeneration with A Novel Synthetic, Bilayered Nanofibrous Dural Substitute: An Experimental Study

• DOI: 10.2217/nnm.10.132
• Publication Date: 2011-03-09T15:28:49Z
• Authors: Kyle Kurpinski; Shyam Patel
• Keywords: Wound Healing; Nanofibers; Transplants; 3T3 Cells; Mice; 03 medical and health sciences; Dogs; 0302 clinical medicine; Biomimetic Materials; Tensile Strength; Wettability; Animals; Regeneration; Female; Dura Mater

Aim: To create a synthetic nanofibrous dural substitute that overcomes the limitations of current devices by enhancing healing via biomimetic nanoscale architecture and supporting both onlaid sutured implantation. Materials & methods: A custom electrospinning process was used to bilayer having aligned nanofibers on one side random other. Nanoscale verified using microscopy macroscale mechanical properties were investigated tensile testing. Biological response this device in vitro canine duraplasty model. Results conclusion: Bilayer nanofiber alignment yields graft anisotropic with significantly higher strength suturability than commercially available collagen matrix. When implanted, prevents leaks brain tissue adhesions, encourages dura mater regrowth, performing comparably Both fibroblast orientation vivo are enhanced nanofibers.