Functional Gold Nanoclusters as Antimicrobial Agents for Antibiotic-Resistant Bacteria

• DOI: 10.2217/nnm.10.43
• Publication Date: 2010-07-22T10:14:13Z
• Authors: Wei-Yu Chen; Ju-Yu Lin; Wei-Jen Chen; Liyang Luo; Eric Wei-Guang Diau; Yu-Chie Chen
• Keywords: Acinetobacter baumannii; Nanoclusters; Pathogenic bacteria; Enterococcus faecalis

Our aim was to demonstrate that lysozyme-directed generation of gold nanoclusters (Au NCs) are potential antimicrobial agents for antibiotic-resistant bacteria and broad labeling pathogenic bacteria.Lysozyme is an enzyme capable hydrolyzing the cell walls bacteria. In this study, we demonstrated functional Au NCs by using lysozyme as sequester reducing agent precursors at 40 degrees C. addition, shorten reaction time, conducted under microwave irradiation within a short period time first time.The bioactivity on retained. Therefore, as-prepared lysozyme-Au with desirable fluorescence feature were successfully employed be broad-band Furthermore, also can used effectively inhibit growth notorious bacteria, including pan-drug-resistant Acinetobacter baumannii vancomycin-resistant Enterococcus faecalis.The employing bacterial expected.