Pharmacogenetic Differentiation Across Latin America

• DOI: 10.2217/pgs-2021-0152
• Publication Date: 2022-01-19T09:55:34Z
• Authors: Guilherme Suarez-...; Gilderlanio Santa...
• Keywords: Genetics, Population; Latin America; Humans; 01 natural sciences; 0104 chemical sciences

Aim: To explore the pharmacogenetic differentiation across Latin American populations, using the fixation index statistics (FST). Materials & methods: FST analyses were applied to 1519 pharmacogenetic markers in the 1000 Genomes admixed American superpopulation (1KG_AMR) and an admixed Brazilian sample. Results: Allele-specific FST values for the overall cohort point to little overall pharmacogenetic differentiation (average FST = 0.017); however, moderate differentiation (FST = 0.05-0.15) was observed for 83 markers, while large differentiation (FST = 0.15-0.25) was restricted to three markers. Pairwise FST analysis identified three markers with very large differentiation (FST >0.25). Conclusion: The present study verifies and extends previous reports of little overall pharmacogenetic divergence across Latin America, although a number of markers display substantial differentiation.