ABCC8 Polymorphism (Ser1369Ala): Influence on Severe Hypoglycemia due to Sulfonylureas

• DOI: 10.2217/pgs.10.135
• Publication Date: 2010-12-13T16:07:36Z
• Authors: Ryosuke Sato; Hiroshi Watanabe; Rieko Genma; Masahiro Takeuchi; Masato Maekawa; Hirotoshi Nakamura
• Keywords: Glimepiride; Sulfonylurea receptor; Sulfonylurea; Gliclazide

Sulfonylureas are categorized according to their binding sites of the ATP-sensitive K+ channel (K(ATP) channel) complex in pancreatic β-cells. The classified as A, B and A + site (both sites), respectively. Ser1369Ala variant sulfonylurea receptor gene ABCC8 which encodes a subunit K(ATP) has been demonstrated be associated with hypoglycemic effect gliclazide, binds site. However, on treatment sulfonylureas, such glimepiride or glibenclamide, is still uncertain.In case-control study, 32 patients Type 2 diabetes admitted hospital severe hypoglycemia 125 consecutive diabetic outpatients without were enrolled. We determined genotypes polymorphism (Ser1369Ala) hypoglycemia. All taking glibenclamide.In treated we found no significant differences distribution genotype between (p = 0.26). Moreover, Ala1369 minor allele tended less frequent group (31 vs 43%; OR: 1.65; 95% CI: 0.92-2.96; p 0.09).Our findings suggest that not major predictive factor due both bind It likely sulfonylureas will mediated by other factors, allele.