Human mandible bone defect repair by the grafting of dental pulp stem/progenitor cells and collagen sponge biocomplexes

• DOI: 10.22203/ecm.v018a07
• Publication Date: 2016-11-25T09:17:48Z
• Authors: R d’Aquino; A De Rosa; V Lanza; V Tirino; L Laino; A Graziano; V Desiderio; G Laino; G Papaccio
• Keywords: Alveolar ridge; Mandible (arthropod mouthpart); Bone grafting; Sponge

In this study we used a biocomplex constructed from dental pulp stem/progenitor cells (DPCs) and collagen sponge scaffold for oro-maxillo-facial (OMF) bone tissue repair in patients requiring extraction of their third molars.The experiments were carried out according to our Internal Ethical Committee Guidelines written informed consent was obtained the patients.The presented with bilateral reabsorption alveolar ridge distal second molar secondary impaction on cortical lamina, producing defect without walls, at least 1.5 cm height.This clinical condition does not permit spontaneous after molar, eventually leads loss also adjacent molar.Maxillary molars extracted first DPC isolation expansion.The then seeded onto fill injury site left by mandibular molars.Three months autologous grafting, had optimal vertical complete restoration periodontal back molars, as assessed probing X-rays.Histological observations clearly demonstrated regeneration site.Optimal evident one year grafting.This demonstrates that DPC/collagen can completely restore human mandible defects indicates cell population could be and/or tissues organs.