Major Advances in Monkeypox Vaccine Research and Development – An Update

• DOI: 10.22207/jpam.16.spl1.08
• Publication Date: 2022-12-29T17:27:36Z
• Authors: Deepak Chandran; V.G. Nandanagopal; Malu Gopan; K. Megha; C.R. Hari Sankar; M.K. Muhammad Aslam; V. Vishnu Savanth; M. Pran; Firzan Nainu; Mohd. Iqbal Yatoo; Mohammad Ebad Ur ...; Hitesh Chopra; Talha Bin Emran; Abhijit Dey; Anil K. Sharma; AbdulRahman A. Saied; Kuldeep Dhama
• Keywords: Monkeypox; Orthopoxvirus; Smallpox vaccine; Poxviridae; Variola virus

Monkeypox (MPX) is a zoonotic disease that endemic to the western and central regions of Africa it caused by monkeypox virus (MPXV), which classified as member Poxviridae family, specifically Chordopoxvirinae subfamily, Orthopoxvirus genus. The current multiregional outbreak MPX, started in May 2022, has since swiftly spread across globe thus been declared global public health emergency World Health Organization (WHO). Protective immunity against MPXV can be achieved administering smallpox vaccination, two viruses share antigenic properties. Although was eradicated 1980, vaccine campaign halted following year, leaving population with significantly less than had before. potential for human-to-human transmission grown result. Due lack particular treatment MPX infection, anti-viral medications initially designed are being employed. However, prognosis may vary depending on factors like immunization history, pre-existing illnesses, comorbidities, even though majority persons who develop have mild, self-limiting illness. Vaccines antiviral drugs researched responses latest 2022 epidemic. first-generation vaccinations maintained national stockpiles several countries not recommended due meeting safety manufacturing criteria, stated WHO. Newer, safer (second- third-generation) vaccines, such JYNNEOSTM, licensed prevention indicated potentially useful interim guideline. Studies vaccines still investigated possible remedies recent outbreak. This mini-review article serves retrospective look at evolution from their inception 1700s trends up end year developing vaccines.