Effects of Isolated or Enriched Housing at Adolescence Upon Ethanol Intake and Anxiety Responses, In Rats Exposed to Prenatal Ethanol

• DOI: 10.22374/jfasrp.v2i1.3
• Publication Date: 2023-02-23T16:37:18Z
• Authors: Paula Di Doi; Macarena Soledad ...; Paola Haeger Soto; Ricardo Pautassi
• Keywords: Prenatal ethanol; 03 medical and health sciences; 0302 clinical medicine; Ethanol; https://purl.org/becyt/ford/3.3; Intake; https://purl.org/becyt/ford/3; Adolescence; 3. Good health

Abstract
 Prenatal alcohol exposure (PAE) is highly prevalent worldwide, and can affect intake anxiety responses in the offspring. It still relatively unknown how PAE interacts with stress at adolescence, there a scarcity of treatments to reduce impact PAE. The present study assessed (ethanol) after tested modulation these by different housing conditions during early adolescence. Pregnant dams were exposed for 22 hours/day, from gestational day 0, throughout pregnancy, until postnatal 7 (PD 7), single bottle 10% ethanol that was mixed tap water sucralose (EtOH Group), or (CTRL Group). During PDs 21-42 offspring standard pair housing, isolated enriched housing. Immediately after, they pair-housed 24-hour access, intermittent 2-bottle choice sessions conducted over 4 weeks, light-dark box test. EtOH exhibited heightened (i.e., greater avoidance white area box) PD21, when compared control (CTRL) rats. Isolated induced area, on 42 70. There no significant versus CTRL differences relative percent preference vs. water) intake, yet overall fluid absolute (g/kg) significantly lower Enriched adolescence had suppressing effect upon first week testing, an more noticeable than indicates associated anxiety-like phenotype. protracted protocol here employed caused generalized reduction behaviours. Environmental enrichment subtle, significant, intake.