Changes of intestinal microbiota in colorectal cancer and its potential ability to predict disease

• DOI: 10.22541/au.166911152.24357479/v1
• Publication Date: 2022-11-22T10:05:41Z
• Authors: Fang Lu; Jie Zhou; Dongjia Lu; Li Ye; Hao Liang; Liuyan Lan; Xiping Yang; Ping Cui; Jiegang Huang
• Keywords: Fusobacterium; Fusobacterium nucleatum; Faecalibacterium prausnitzii; Peptostreptococcus

Background： It is controversial whether colorectal cancer (CRC) impacts intestinal microbial alpha (α) diversity, and although some studies have suggested an association between microbiota risk, few been used as a marker for CRC diagnosis. Methods： By searching PubMed BioProject databases, we reanalysed published raw 16S ribosomal RNA (rRNA) gene sequences metadata. We calculated α-diversity indices, screened the differentially enriched genera species shared among different studies, identified potential markers, finally assessed overall trend of these indices. Results： The pooled analysis showed that based on fixed-effects model, group was lower than non-cancer group, there significant heterogeneity. Heterogeneity significantly reduced or eliminated when grouped by geographic region, study scope, sequencing platform. also found gut CRC. Fusobacterium , Parvimonas Gemella Campylobacter Peptostreptococcus were only in while Faecalibacterium, Subdoligranulum Fusicatenibacter dominant group. At same time, provide evidence Faecalibacterium diagnostic value several may be markers Conclusions： This indicates composition, could indicators However, future should include more cohorts wide sample sizes to identify role