Post-COVID Syndrome and health-related quality of life (HrQoL): A prospective, population-based study

• DOI: 10.22541/au.172464977.75584057/v1
• Publication Date: 2024-08-26T05:23:03Z
• Authors: Christian Neumann; Tim J. Hartung; Klara Boje; Thomas Bahmer; Julian Keil; Wolfgang Lieb; Katrin Franzpoetter; Julius Welzel; Irina Chaplinskay...; Matthias Endres; Johanna Geritz; Karl Georg Haeusler; Peter Heuschmann; Andreas Hinz; Sina Hopff; Anna Horn; Carolin Nuernberger; Lena Schmidbauer; Michael Krawczak; Anne-Kathrin Ruß; Lilian Krist; Thomas Keil; Jennifer Kudelka; Corina Maetzler; Anja Mehnert-Theu...; Felipe A. Montellano; Caroline Morbach; Sein Schmidt; Jan Heyckendorf; Flo Steigerwald; Stefan Stoerk; Christina Lemhoefer; Stefan Schreiber; Carsten Finke; Walter Maetzler
• Keywords: Depression

Long-term changes in health-related quality of life (HrQoL) after SARS-CoV-2 infection are common, but the causes and consequences these not well understood. HrQoL was assessed using European Quality-of-Life-5-Dimensions-5-Level-Version (EQ-5D-5L) 2,618 participants (56% female; aged 18–88 years) approximately 9 months (baseline) 26 (follow-up) their first infection. The results were compared to 40 different demographic clinical variables. A clinically important improvement noted during observation period. At baseline, number remaining symptoms from (RS), fatigue (FACIT-Fatigue Scale), depressive (PHQ-8), muscle pain, age, anxiety (GAD-7) explained 43% variance HrQoL. follow-up, fatigue, RS, symptoms, anxiety, pain 50% variance. Although RS associated with a change HrQoL, predictive value variables virtually zero. study suggests that improves statistically significantly However, extent recovery is difficult predict concurrent Besides high number, main predictor poor infection, followed by presence symptoms.