Efficacy of vitamin B1 in alleviating chemotherapy-induced nausea and vomiting

• DOI: 10.22541/au.172490858.80962113/v1
• Publication Date: 2024-08-29T05:16:29Z
• Authors: Satoru Matsushima; Hirozumi Sano; Daiki Hori; Masato Yanagi; Daisuke Suzuki; Ryoji Kobayashi

Background. The management of chemotherapy-induced nausea and vomiting (CINV) is primary concern for both patients with cancer medical workers. Refractory or breakthrough CINV especially difficult to deal necessitates a different approach. Vitamin B1 deficiency likely occur during chemotherapy, early symptoms fatigue, anorexia, vomiting. efficacy vitamin the treatment delayed refractory should be confirmed. Methods. Serum level was prospectively measured in experiencing persistent after chemotherapy. response therapy evaluated three consecutive days infusion. Moreover, serum at diagnosis compared before Results. In total, 408 courses chemotherapy 86 were analyzed. median age hospital admission enrolled 10.7 years (0.2–25.2). Among these, 44 (10.8%) episodes identified 26 patients. At day 3, overall rate 79.5%; 21 (47.7%) achieved complete 14 (31.8%) partial response. significantly lower than value (22.8, range 11.9–49.2 vs. 32.7, 11.2−80.1, respectively, P < 0.001). Conclusion. Patients malignant disease who experience often exhibit deficiency. infusion may beneficial many these