Potential New Tumors Associated with Hereditary Breast and Ovarian Cancer (HBOC)

• DOI: 10.2302/kjm.2024-0023-re
• Publication Date: 2025-03-11T22:12:01Z
• Authors: Kohei Nakamura; Kenta Masuda; Tomoko Seki; Minoru Kitago; Takeo Kosaka; Yumiko Goto; Mamiko Yamada; Kumiko Misu; Ikumi Ono; Yusuke Kobayashi; Wataru Yamagami

Hereditary breast and ovarian cancer syndrome (HBOC) is traditionally associated with mutations in the BRCA1 BRCA2 genes, predominantly impacting breast, ovarian, pancreatic, prostate cancers. However, recent research suggests that these may also predispose carriers to a broader spectrum of malignancies, including biliary tract, cervical, colorectal, endometrial, esophageal, gastric This review presents findings from extensive datasets, significant study nationwide Japanese biobank examined risks 63,828 patients 37,086 controls. Our highlights notable associations, such as an increased risk uterine cervical cancers mutation esophageal carriers. These emerging associations underscore necessity revisiting potentially expanding current clinical guidelines incorporate additional risks. advocate comprehensive approach genetic counseling importance tailored surveillance strategies populations carrying BRCA mutations. expanded understanding could significantly influence preventive, diagnostic, therapeutic strategies, promoting personalized approaches manage prevent malignancies genetically susceptible populations.