Protein Adduct Biomarkers: State of the Art

• DOI: 10.2307/3433005
• Publication Date: 2007-03-10T03:06:30Z
• Authors: Mark J. Meyer; William E. Bechtold
• Keywords: 0301 basic medicine; DNA Adducts; 0303 health sciences; 03 medical and health sciences; Humans; Proteins; Biomarkers; Environmental Monitoring; 3. Good health

Covalent protein adducts formed after exposure to xenobiotics may provide readily measurable indicators of these exposures.After adequate characterization the dose-dependent formation a specific adduct, adduct can often be used as quantitative marker for exposure, DNA formation, or, possibly, risk disease.By elucidating structure an and studying conditions under which it forms, information about reactions that lead its obtained.Continuing work in this area includes methods expand number, types, levels chemical exposures studied by covalent formation.In addition use technology field occupational health, basic research provides insights into metabolic pathways biochemistry, well.