Binucleate Cell Formation Induced by X Irradiation

• DOI: 10.2307/3574929
• Publication Date: 2006-11-16T16:24:58Z
• Authors: S. Kura; H. Sasaki; R. Aramaki; H. Yoshinaga
• Keywords: Cell Nucleus; Time Factors; Cell Survival; X-Rays; DNA, Neoplasm; Radiation Dosage; Transplantable Tumors:; Radiation:; Cell Line; Cell Fusion; 03 medical and health sciences; 0302 clinical medicine; Types of Tumors:; Strains:; Cellular Biology:; Tissue Culture:; Neoplasm:; Cell Division

The kinetics of binucleate cell formation and their relationship to the recovery primary damage were investigated using mouse mammary carcinoma cells (FM3A) grown in suspension. following results obtained: (i) percentage increased with dose a maximum on second or third day postirradiation when rate proliferation was at minimum; (ii) smaller two split doses (2 × 500 rad, 4-hr interval) than single (1000-rad) dose; (iii) decreased treatment Hanks' balanced salt solution (HBSS) immediately (1000 rad). These suggest that radiation-induced plays an important role reproductive death.