Production of Humoral Factors That Stimulate Spleen Colony-Forming Units in Mice Irradiated with Moderate Doses of X Rays

• DOI: 10.2307/3577582
• Publication Date: 2006-11-16T22:17:12Z
• Authors: Teresa Grande; Joaquina González; Concepción Tejero; Gabriel Maganto; Juan A. Bueren; Joaquina Gonzalez; Concepcion Tejero
• Keywords: Radiosensitivity

The production of humoral factors that stimulate spleen colony-forming units (CFU-S) has been studied in irradiated mice using an vivo diffusion chamber assay. experiments show a significant release CFU-S takes place the first few days after irradiation with moderate doses 1.5 or 5 Gy. In contrast, amounts these was not seen animals either low (0.75 Gy) high (10 X rays. correlation observed between and hemopoietic regeneration kinetics suggests represent part physiological regulators controlling proliferation CFU-S.