Hepatic Radiation Injury in the Rat

• DOI: 10.2307/3577983
• Publication Date: 2006-11-16T17:21:00Z
• Authors: J. P. Geraci; M. S. Mariano; K. L. Jackson
• Keywords: Rose bengal; Transaminase; Histology; Liver function

The whole livers of rats were exposed intraoperatively to graded doses (0 75 Gy) 137Cs gamma radiation. At various times 155 days) after liver irradiation, minimally invasive, nondestructive tests (rose bengal retention and plasma alkaline phosphatase, glutamic-oxaloacetic acid transaminase, glutamic-pyruvic transaminase) performed on at least half the surviving animals in each dose group assess developing injury. Liver histology was done sacrificed 96 100 days irradiation. Radiation damage stomach killed approximately 50% 30 60 exposure 25 Gy or higher. These deaths significantly reduced when care taken shield during Stomach injury did not, however, appreciably affect function as measured by rose retention. Whole-liver irradiation 15 resulted size minimal histological changes, but not result increased phosphatase concentration. next highest studied (25 showed significant abnormalities enzymes. latent period for development hepatic injury, retention, 35 42 relatively invariant over 25- 75-Gy range. Hepatic vein lesions cellular necrosis most prominent observed 25-Gy-irradiated liver.