A Preliminary Investigation into the Extent of Increased Radioresistance or Hyper-Radiosensitivity in Cells of Hamster Cell Lines Known to Be Deficient in DNA Repair

• DOI: 10.2307/3578779
• Publication Date: 2006-11-16T17:40:13Z
• Authors: Kirsten Skov; Brian Marples; Jeffrey B. Matthews; Michael C. Joiner; Haibo Zhou
• Keywords: Radioresistance; Radiosensitivity

The response to low doses of X rays was assessed in cells three hamster cell lines which are defective DNA repair and compared with their parental lines. Cells the V79-derived double-strand break repair-deficient line XR-V15B showed no radioresistance 0.5-Gy range V79B wild type, but instead an exponential response. single-strand EM9 hyper-radiosensitivity exhibited increased radioresistance. Most interestingly, UV-20 appeared respond exponentially, as a continuation hyper-radiosensitive portion curve, evidence This is incision step excision sensitive crosslinking agents. Further studies warranted address possible role single-