Urinary Eosinophil-derived Neurotoxin Concentrations in Patients with Atopic Dermatitis: A Useful Clinical Marker for Disease Activity

• DOI: 10.2332/allergolint.o-07-489
• Publication Date: 2007-12-27T05:49:46Z
• Authors: Tomoko Goto; Junichiro Morioka; Hiroaki Inamura; Megumi Yano; Kazumi Kodaira; Yasushi Igarashi; Shyuzo Abe; Motohiro Kurosawa
• Keywords: Adult; Male; atopic dermatitis; Adolescent; Eosinophil-Derived Neurotoxin; RC581-607; eosinophil-derived neurotoxin; Severity of Illness Index; Dermatitis, Atopic; 3. Good health; visual analogue scale; Eosinophils; 03 medical and health sciences; 0302 clinical medicine; Humans; eosinophil; Female; Immunologic diseases. Allergy; Biomarkers; Pain Measurement

It has been reported that measurements of eosinophil-derived neurotoxin (EDN) may be useful for identifying eosinophil activities in allergic diseases including atopic dermatitis.EDN concentrations in the urine were measured by enzyme-linked immunosorbent assay, and the number of eosinophils in the peripheral blood was counted in 30 patients with atopic dermatitis. The severity of atopic dermatitis was graded on the criteria proposed by Rajka and Langeland. The disease activity was assessed by each patient on a visual analogue scale (VAS).Urinary concentrations of EDN in patients with atopic dermatitis showed a significant positive correlation with disease severity. Urine EDN concentrations also correlated with VAS scores for itching, skin condition, overall skin symptoms and total VAS score, but not with the VAS score for skin dryness. Urinary EDN concentrations did not correlate with the number of eosinophils in the peripheral blood.The urinary EDN concentration in patients with atopic dermatitis is a useful clinical marker for monitoring disease activity.