The Class I HLA Repertoire of Pancreatic Islets Comprises the Nonclassical Class Ib Antigen HLA-G

• DOI: 10.2337/db05-0731
• Publication Date: 2006-05-10T22:48:46Z
• Authors: Vincenzo Cirulli; Jessie Zalatan; Michael McMaster; Robyn Prinsen; Daniel R. Salomon; Camillo Ricordi; Bruce E. Torbett; Paolo Meda; Laura Crisa
• Keywords: Pancreatic Islets; Antigen processing

Selective expression of the human class Ib HLA molecule HLA-G in immunologically protected sites and its function inhibition NK T-cell effector functions support an important role this immunoregulation. Here, we demonstrate that is constitutively expressed endocrine compartment pancreas. Surface determinant cells regulated response to growth inflammatory stimuli. Furthermore, provide evidence tissue may associate with a subset insulin-containing granules be shuttled cell surface secretory Thus, presentation by concert their activity. These results identify major histocompatibility complex locus putative regulatory pancreatic islets, finding potentially implications for progression autoimmunity as well establishment transplant tolerance tissue.