Downregulation of Electron Transport Chain Genes in Visceral Adipose Tissue in Type 2 Diabetes Independent of Obesity and Possibly Involving Tumor Necrosis Factor-α

• DOI: 10.2337/db05-1421
• Publication Date: 2006-05-26T20:00:23Z
• Authors: Ingrid Dahlman; Margaretha Forsgren; Annelie Sjögren; Elisabet Arvidsso...; Maria Kaaman; Erik Näslund; Anneli Attersand; Peter Arner
• Keywords: Adipose tissue macrophages

Impaired oxidative phosphorylation is suggested as a factor behind insulin resistance of skeletal muscle in type 2 diabetes. The role adipose tissue was elucidated from results Affymetrix gene profiling subcutaneous and visceral eight nonobese healthy, obese diabetic women. Downregulation several genes the electron transport chain most prominent finding fat women independent obesity, but pattern distinct that previously reported A similar much weaker effect observed fat. Tumor necrosis factor-alpha (TNF-alpha) major inflammation tissue. TNF-alpha treatment decreased mRNA expression also inhibited fatty acid oxidation when differentiated human preadipocytes were treated with cytokine for 48 h. Thus, diabetes associated tissue- region-specific downregulation obesity at least part mediated by TNF-alpha, suggesting impaired has pathogenic importance development