Glucagon-Like Peptide 1 Secretion by the L-Cell

• DOI: 10.2337/db06-s020
• Publication Date: 2006-12-14T18:43:02Z
• Authors: Gareth E. Lim; Patricia L. Brubaker
• Keywords: Enteroendocrine cell; Peptide YY; Gastrointestinal hormone

Glucagon-like peptide 1 (GLP-1) is a gut-derived secreted from intestinal L-cells after meal. GLP-1 has numerous physiological actions, including potentiation of glucose-stimulated insulin secretion, enhancement β-cell growth and survival, inhibition glucagon release, gastric emptying, food intake. These antidiabetic effects have led to intense interest in the use this for treatment patients with type 2 diabetes. Oral nutrients such as glucose fat are potent regulators but non-nutrient stimulators release also been identified, neuromodulators acetylcholine gastrin-releasing peptide. Peripheral hormones that participate energy homeostasis, leptin, implicated regulation release. Recent studies begun elucidate intracellular signaling pathways mediate secretagogues on L-cell. The purpose review summarize known mechanisms based available literature. A better understanding underlying secretion may lead novel approaches by which levels important insulinotropic hormone can be enhanced