Cholinergic Regulation of Ghrelin and Peptide YY Release May Be Impaired in Obesity

• DOI: 10.2337/db07-0758
• Publication Date: 2008-06-21T01:36:46Z
• Authors: Christina Maier; Michaela Riedl; Greisa Vila; Peter Nowotny; Michael Wolzt; Martin Clodi; Bernhard Ludvik; Anton Luger
• Keywords: Peptide YY; Crossover study; Pancreatic polypeptide

Ghrelin and peptide YY (PYY) are both hormones derived from the gastrointestinal tract involved in appetite regulation. The cholinergic part of vagal nerve is regulation glucose insulin. aim this study was to examine effects antagonist atropine on ghrelin, PYY, glucose, insulin under basal conditions after meal ingestion lean obese subjects.Eight eight subjects were included a randomized, double-blind, placebo-controlled crossover with 4 days randomized order (atropine/placebo +/- breakfast). Plasma insulin, measured. Hunger satiety feelings rated 10-cm visual analog scale.In individuals, led decrease ghrelin concentrations comparable nonadditive breakfast significant meal-induced PYY concentrations. In subjects, did not significantly change or concentrations, whereas it induced increase heart rate two groups. Only lean, obese, experienced sustained breakfast.The impaired postprandial drop rise might be deregulated food intake subjects.