β-Cell Replication Is the Primary Mechanism Subserving the Postnatal Expansion of β-Cell Mass in Humans

Adult Aging 0303 health sciences Adolescent Infant, Newborn Infant Organ Size 03 medical and health sciences Child, Preschool Insulin-Secreting Cells Humans Child Pancreas Cell Division
DOI: 10.2337/db07-1369 Publication Date: 2008-03-12T03:34:23Z
ABSTRACT
OBJECTIVE— Little is known about the capacity, mechanisms, or timing of growth in β-cell mass humans. We sought to establish if predominant expansion humans occurs early childhood and if, as rodents, this coincides with relatively abundant replication. also there a secondary coincident accelerated somatic adolescence. RESEARCH DESIGN AND METHODS— To address these questions, pancreas volume was determined from abdominal computer tomographies 135 children aged 4 weeks 20 years, morphometric analyses were performed human pancreatic tissue obtained at autopsy 46 2 21 years. RESULTS— report that 1) expands by severalfold birth adulthood, 2) islets grow size rather than number during transition, 3) relative rate highest infancy gradually declines thereafter adulthood no phase adolescence, 4) (and presumably growth) highly variable between individuals, 5) high replication major postnatal mass. CONCLUSIONS— These data imply regulation plays role adult
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